Hereditary or “predisposition” genetic testing looks for specific inherited changes (variants, or mutations) in a person’s genetic make-up. Genetic variations can have harmful, beneficial, neutral, or uncertain effects on health. Harmful mutations may increase a person’s chance of developing cancer. Inherited mutations are thought to play a role in 5-10% of all cancers known as hereditary cancers.
Cancer is a disorder in which normal control of cell growth is lost-causing abnormal proliferation of the affected cells. Inherited genetic changes can increase a person’s risk of developing cancer through a variety of mechanisms, depending on the function of the mutated gene.
Advancements in gene sequencing technologies have allowed for genetic mutations that cause many hereditary cancers to be well described, and sophisticated mutation screening can confirm whether a cancer is, indeed, the result of an inherited variation. Genetic testing is also performed to determine whether asymptomatic individuals with family members affected by cancer may have inherited the causal genetic mutation.
Note: An individual’s familial cancer history may include a number of seemingly distinct cancer cases. This erroneously leads to the belief that the cancers are un-related, and not caused by a hereditary mutation. On the contrary, some variants can contribute to very different and disparate cancers. (i.e. EPCAM can lead to Colon Cancer, Endometrial Cancer, Lynch Syndrome, melanoma, pancreatic, and prostate cancer)
The sooner genetic testing is performed, the more likely it is that this increased risk can be managed appropriately.
As a Healthcare Professional, you are the most valuable source of information
Collection Devices and Specimen Requirements
Extracted DNA: >20μg (please inquire as to proper protocol for acceptance)