PREDICT™ Comprehensive Hereditary Cancer Risk Assessment

LabSolutions is pleased to offer its clients a comprehensive suite of genetic risk tests, allowing the physicians we serve to provide truly personalized healthcare. PREDICT test results, along with a treating physician’s expertise, are used to make better informed treatment and/or monitoring decisions.

Introduction

Hereditary or “predisposition” genetic testing looks for specific inherited changes (variants, or mutations) in a person’s genetic make-up. Genetic variations can have harmful, beneficial, neutral, or uncertain effects on health. Harmful mutations may increase a person’s chance of developing cancer. Inherited mutations are thought to play a role in 5-10% of all cancers known as hereditary cancers.

Cancer is a disorder in which normal control of cell growth is lost-causing abnormal proliferation of the affected cells. Inherited genetic changes can increase a person’s risk of developing cancer through a variety of mechanisms, depending on the function of the mutated gene.

Advancements in gene sequencing technologies have allowed for genetic mutations that cause many hereditary cancers to be well described, and sophisticated mutation screening can confirm whether a cancer is, indeed, the result of an inherited variation. Genetic testing is also performed to determine whether asymptomatic individuals with family members affected by cancer may have inherited the causal genetic mutation.

Examples of Common Hereditary Cancers and Cancer Syndromes

  • Hereditary Breast and Ovarian Cancer (BRCA 1/2)
  • Colon Cancer (APC, BMPR1A, EPCAM)
  • Uterine Cancer (MLH1, MSH2, EPCAM, MSH6, PMS2)
  • Endometrial Cancer (EPCAM, MLH1, MSH2, MSH6)
  • Lynch Syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM, MUTYH)
  • Cowden Syndrome (PTEN)
  • Li-Fraumeni Syndrome (TP53)

Who Should Get Tested

  • Abnormal Family History
  • Membership in an at-risk ethnic population (such as Ashkenazi Jewish ancestry)
  • If one of your family members (even distant), has been diagnosed with cancer

Note: An individual’s familial cancer history may include a number of seemingly distinct cancer cases. This erroneously leads to the belief that the cancers are un-related, and not caused by a hereditary mutation. On the contrary, some variants can contribute to very different and disparate cancers. (i.e. EPCAM can lead to Colon Cancer, Endometrial Cancer, Lynch Syndrome, melanoma, pancreatic, and prostate cancer)

Benefits of Testing

The sooner genetic testing is performed, the more likely it is that this increased risk can be managed appropriately.

  • Protocols may suggest the increased use of routine screening tools like mammograms and colonoscopies
  • Extreme protocols may suggest consideration of more aggressive options like prophylactic surgical intervention

As a Healthcare Professional, you are the most valuable source of information

Collection Devices and Specimen Requirements

  • Whole blood: 2 EDTA (lavender top) tubes containing 4 mL each whole sterile blood.
  • Oral Fluids: Saliva collected using the LabSolutions Oral Fluid collection kit

Extracted DNA: >20μg (please inquire as to proper protocol for acceptance)